VOLUME 1
Part I
Biology of the Gastrointestinal tract
1 Cellular Growth and Neoplasia, 1
Ezra Burstein
2 Mucosal Immunology and Inflammation, 13
CIharles O. Elson and Phillip D. Smith
3 The Enteric Microbiota, 24
Eugene B. Chang and Purna Kashyap
4 Gut Sensory Transduction, 34
Diego V. Bohórquez and Rodger A. Liddle
Part II
Nutrition in Gastroenterology
5 Nutritional Principles and Assessment of the Gastroenterology Patient, 52
Joel B. Mason
6 Nutritional Management, 74
Angela K. Pham and Stephen A. McClave
7 Obesity, 92
Rekha B. Kumar and Louis J. Aronne
8 Surgical and Endoscopic Treatment of Obesity, 101
Shelby Sullivan, Steven A. Edmundowicz, and John Magaña Morton
9 Feeding and Eating Disorders, 117
Debra K. Katzman and Mark L. Norris
10 Food Allergies, 133
J. Andrew Bird
Part III
Symptoms, Signs, and Biopsychosocial Issues
11 Acute Abdominal Pain, 144
Frederick H. Millham
12 Chronic Abdominal Pain, 158
Joseph C. Yarze and Lawrence S. Friedman
13 Symptoms of Esophageal Disease, 168
Kenneth R. DeVault
14 Dyspepsia,177
Jan Tack
15 Nausea and Vomiting, 191
Arvind Rengarajan and C. Prakash Gyawali
16 Diarrhea, 204
Lawrence R. Schiller and Joseph H. Sellin
17 Intestinal Gas,224
Fernando Azpiroz
18 Fecal Incontinence,232
Satish S.C. Rao
19 Constipation,250
Johanna C. Iturrino and Anthony J. Lembo
20 Gastrointestinal Bleeding, 276
Thomas J. Savides and Dennis M. Jensen
21 Jaundice, 313
Steven D. Lidofsky
22 Biopsychosocial Issues in Gastroenterology,324
Douglas A. Drossman and Laurie Keefer
23 Factitious Gastrointestinal Disease,340
John S. Fordtran and Anahit A. Zeynalyan
Part IV
topics Involving Multiple Organs
24 Oral Diseases and Oral Manifestations of Gastrointestinal and Liver Diseases, 350
Kimberly L. Pham and Ginat W. Mirowski
25 Cutaneous Manifestations of Gastrointestinal and Liver Diseases, 359
Lawrence A. Mark
26 Diverticula of the Pharynx, Esophagus, Stomach, and Small Intestine, 372
Kerry B. Dunbar and D. Rohan Jeyarajah
27 Abdominal Hernias and Gastric Volvulus, 381
D. Rohan Jeyarajah and Kerry B. Dunbar
28 Foreign Bodies, Bezoars, and Caustic Ingestions, 399
Patrick R. Pfau and Mark Benson
29 Abdominal Abscesses and Gastrointestinal Fistulas, 411
Gregory dePrisco, Scott Celinski, and Cedric W. Spak
30 Eosinophilic Disorders of the Gastrointestinal Tract, 424
Marc E. Rothenberg and Vidhya Kunnathur
31 Protein-Losing Gastroenteropathy, 435
David A. Greenwald
32 Gastrointestinal Lymphomas, 442
Praveen Ramakrishnan Geethakumari and Syed Mujtaba Rizvi
33 Gastrointestinal Stromal Tumors, 458
Margaret von Mehren
34 Neuroendocrine Tumors, 472
Jonathan R. Strosberg and Taymeyah Al-Toubah
35 Gastrointestinal Consequences of Infection with Human Immunodeficiency Virus, 498
C. Mel Wilcox
36 Gastrointestinal and Hepatic Complications of Solid Organ and Hematopoietic Cell Transplantation, 510
Anne M. Larson, Rachel B. Issaka, and David M. Hockenbery
37 Gastrointestinal and Hepatic Manifestations of Systemic Diseases, 532
Frederick Weber
38 Vascular Lesions of the Gastrointestinal Tract, 561
Joann Kwah and Lawrence J. Brandt
39 Surgical Peritonitis and Other Diseases of the Peritoneum, Mesentery, Omentum, and Diaphragm, 580
Jeffrey B. Matthews and Kiran Turaga
40 Gastrointestinal and Hepatic Disorders in the Pregnant Patient, 593
Shilpa Mehra and John F. Reinus
41 Acute and Chronic Gastrointestinal Side Effects of Radiation Therapy, 606
Jarred P. Tanksley, Christopher G. Willett, Brian G. Czito, and Manisha Palta
42 Preparation for and Complications of Gastrointestinal Endoscopy, 619
Aravind Sugumar and John J. Vargo II
Part V Esophagus
43 Anatomy, Histology, Embryology, and Developmental Anomalies of the Esophagus,627
Ryan D. Madanick and Vishal Kaila
44 Esophageal Neuromuscular Function and Motility Disorders, 638
John E. Pandolfino and Peter J. Kahrilas
45 Esophageal Disorders Caused by Medications, Trauma, and Infection, 661
David A. Katzka
46 Gastroesophageal Reflux Disease, 670
Joel E. Richter and Michael F. Vaezi
47 Barrett Esophagus, 691
Stuart Jon Spechler and Rhonda F. Souza
48 Esophageal Tumors, 700
Hazem Hammad and Sachin Wani
Part VI
Stomach and Duodenum
49 Anatomy, Histology and Developmental Anomalies of the Stomach and Duodenum, 720
M. Gaith Semrin
50 Gastric Neuromuscular Function and Neuromuscular Disorders, 735
Kenneth L. Koch
51 Gastric Secretion,764
Mitchell L. Schubert and Jonathan D. Kaunitz52 Gastritis and Gastropathy, 781
Mark Feldman, Pamela J. Jensen, and Colin W. Howden
53 Peptic Ulcer Disease, 806
Francis K.L. Chan and James Y.W. Lau
54 Adenocarcinoma of the Stomach and Other Gastric Tumors, 820
Michael Quante and Jan Bornschein
Part VII
Pancreas
55 Anatomy, Histology, Embryology, and Developmental Anomalies of the Pancreas, 842
Megha S. Mehta, Bradley A. Barth, and Sohail Z. Husain
56 Pancreatic Secretion, 853
Stephen J. Pandol
57 Genetic Disorders of the Pancreas and Pancreatic Disorders in Childhood, 862
David C. Whitcomb and Mark E. Lowe
58 Acute Pancreatitis, 893
Santhi Swaroop Vege
59 Chronic Pancreatitis, 917
Chris E. Forsmark
60 Pancreatic Cancer, Cystic Pancreatic Neoplasms, and Other Nonendocrine Pancreatic Tumors, 947
Bijal Modi and G. Thomas Shires
61 Endoscopic Treatment of Pancreatic Disease, 965
Ryan Law and Todd H. Baron
Part VIII
Biliary tract
62 Anatomy, Histology, Embryology, Developmental Anomalies, and Pediatric Disorders of the Biliary Tract, 973
Frederick J. Suchy and Cara L. Mack
63 Biliary Tract Motor Function and Dysfunction, 995
B. Joseph Elmunzer and Grace H. Elta
64 Bile Secretion and the Enterohepatic Circulation, 1001
Peter Fickert and Paul A. Dawson
65 Gallstone Disease, 1016
David Q.-H. Wang and Nezam H. Afdhal
66 Treatment of Gallstone Disease, 1047
Robert E. Glasgow
67 Acalculous Biliary Pain, Acute Acalculous Cholecystitis, Cholesterolosis, Adenomyomatosis, and Gallbladder Polyps, 1064
Karin L. Andersson and Lawrence S. Friedman
68 Primary and Secondary Sclerosing Cholangitis, 1077
Cynthia Levy and Christopher L. Bowlus
69 Tumors of the Bile Ducts, Gallbladder, and Ampulla, 1096
Sumera H. Rizvi and Gregory J. Gores
70 Endoscopic and Radiologic Treatment of Biliary Disease, 1113
Theodore W. James and Todd H. Baron
VOLUME 2
Part IX
Liver
71 Embryology, Anatomy, Histology, and Developmental Anomalies of the Liver,1129
Ricard Masia and Joseph Misdraji
72 Liver Physiology and Energy Metabolism, 1135
Namita Roy-Chowdhury and Jayanta Roy-Chowdhury73 Liver Chemistry and Function Tests, 1154
Daniel S. Pratt
74 Overview of Cirrhosis, 1164
Patrick S. Kamath and Vijay H. Shah
75 Hemochromatosis, 1172
Bruce R. Bacon and Robert E. Fleming
76 Wilson Disease, 1180
Eve A. Roberts
77 Other Inherited Metabolic Disorders of the Liver, 1189
James E. Squires and William F. Balistreri
78 Hepatitis A, 1210
Maria H. Sjogren and Joseph G. Cheatham
79 Hepatitis B, 1216
Harry L.A. Janssen and Scott Fung
80 Hepatitis C, 1243
Jacinta A. Holmes and Raymond T. Chung
81 Hepatitis D, 1283
Marc G. Ghany
82 Hepatitis E, 1292
Rakesh Aggarwal
83 Hepatitis Caused by Other Viruses, 1298
Jordan J. Feld
84 Bacterial, Parasitic, and Fungal Infections of the Liver, Including Liver Abscesses, 1303
Arthur Y. Kim and Raymond T. Chung
85 Vascular Diseases of the Liver, 1321
Filipe Gaio Nery and Dominique Charles Valla
86 Alcohol-Associated Liver Disease, 1336
Gyongyi Szabo and Craig J. McClain
87 Nonalcoholic Fatty Liver Disease, 1354
Dawn M. Torres and Stephen A. Harrison
88 Liver Disease Caused by Drugs, 1367
Shivakumar Chitturi, Narci C. Teoh, and Geoffrey C. Farrell
89 Liver Disease Caused by Anesthetics, Chemicals, Toxins, and Herbal and Dietary Supplements, 1399
James H. Lewis
90 Autoimmune Hepatitis, 1415
Albert J. Czaja
91 Primary Biliary Cholangitis, 1433
John E. Eaton and Keith D. Lindor
92 Portal Hypertension and Variceal Bleeding, 1443
Vijay H. Shah and Patrick S. Kamath
93 Ascites and Spontaneous Bacterial Peritonitis, 1471
Elsa Solà and Pere Ginès
94 Hepatic Encephalopathy, Hepatorenal Syndrome, Hepatopulmonary Syndrome, and Other Systemic Complications of Liver Disease, 1486
Shivang S. Mehta and Michael B. Fallon
95 Acute Liver Failure, 1499
John O’Grady and William Bernal
96 Hepatic Tumors and Cysts, 1509
Adrian M. Di Bisceglie and Alex S. Befeler
97 Liver Transplantation, 1533
Andres F. Carrion and Paul Martin
Part X
Small and Large Intestine
98 Anatomy, Histology, Embryology, and Developmental Anomalies of the Small and Large Intestine, 1551
Lee M. Bass and Barry K. Wershil
99 Small Intestinal Motor and Sensory Function and Dysfunction, 1580
Christopher K. Rayner and Patrick A. Hughes
100 Colonic Motor and Sensory Function and Dysfunction, 1595
Philip G. Dinning, Marcello Costa, and Simon J.H. Brookes
101 Intestinal Electrolyte Absorption and Secretion, 1611
Mrinalini C. Rao and Jayashree Sarathy
102 Digestion and Absorption of Carbohydrate, Protein, and Fat, 1636
Yangzom D. Bhutia and Vadivel Ganapathy
103 Digestion and Absorption of Micronutrients, 1657
Michelle Pearlman and Jaime Almandoz
104 Maldigestion and Malabsorption, 1677
Christoph Höegenauer and Heinz F. Hammer
105 Small Intestinal Bacterial Overgrowth, 1711
Brian E. Lacy and John K. DiBaise
106 Short Bowel Syndrome, 1720
Alan L. Buchman
107 Celiac Disease, 1736
Benjamin Lebwohl and Peter H.R. Green
108 Tropical Diarrhea and Malabsorption, 1756
Balakrishnan S. Ramakrishna
109 Whipple Disease, 1769
Matthias Maiwald, Axel von Herbay, and David A. Relman
110 Infectious Enteritis and Proctocolitis, 1779
Joanna M.P. Melia and Cynthia L. Sears
111 Food Poisoning, 1810
Jennifer Katz
112 Antibiotic-Associated Diarrhea and Clostridioides difficile Infection, 1818
Ciarán P. Kelly and Sahil Khanna
113 Intestinal Protozoa, 1834
Christopher D. Huston
114 Intestinal Worms, 1847
M. Nedim Ince and David E. Elliott
115 Epidemiology, Pathogenesis, and Diagnosis of Inflammatory Bowel Diseases, 1868
Gilaad G. Kaplan and Siew C. Ng
116 Management of Inflammatory Bowel Diseases, 1898
Ashwin N. Ananthakrishnan and Miguel D. Regueiro
117 Ileostomies, Colostomies, Pouches, and Anastomoses, 1930
Ahsan Raza and Farshid Araghizadeh
118 Intestinal Ischemia, 1944
Paul Feuerstadt and Lawrence J. Brandt
119 Intestinal Ulcerations, 1970
Blair Lewis and Daniel S. Mishkin
120 Appendicitis,1983
Martin Daniel Rosenthal and George S. Sarosi, Jr.
121 Diverticular Disease of the Colon, 1993
Taft P. Bhuket and Neil H. Stollman
122 Irritable Bowel Syndrome, 2008
Alexander C. Ford and Nicholas J. Talley
123 Intestinal Obstruction, 2021
William Conan Mustain and Richard H. Turnage
124 Ileus and Pseudo-Obstruction Syndromes, 2039
Adil E. Bharucha and David O. Prichard
125 Tumors of the Small Intestine, 2059
Boris Blechacz and Robert Scott Bresalier
126 Colonic Polyps and Polyposis Syndromes, 2076
John J. Garber and Daniel C. Chung
127 John J. Garber and Daniel C. Chung Colorectal Cancer, 2108
Robert Scott Bresalier
128 Other Diseases of the Colon, 2153
Darrell S. Pardi and Thomas G. Cotter
129 Anal Diseases, 2169
J. Marcus Downs and Benjamin Kulow
Part XI
additional treatments for Patients with Gastrointestinal and Liver Disease
130 Probiotics, 2187
Eamonn M.M. Quigley
131 Complementary, Alternative, and Integrative Medicine, 2192
Jill K. Deutsch and David J. Hass
132 Palliative Care Medicine in Patients with Advanced Gastrointestinal and Hepatic Disease, 2206
Vyjeyanthi S. Periyakoil, Nielsen Fernandez-Becker, and Sarah E. Streett